CYP450 Enzim Tablosu

 

CYP450 SUBSTRATES

1A2

2B6

2C19

2D6

3A4

amitriptyline
clomipramine
imipramine

fluvoxamine
duloxetine
mirtazapine

chlorpromazine
fluphenazine
haloperidol
perphenazine

clozapine
olanzapine
ziprasidone

ropinirole

ALL methylxanthines

selegiline

bupropion

methadone

amitriptyline
clomipramine
imipramine

diazepam

phenytoin
phenobarbital

citalopram
escitalopram
fluoxetine
sertraline

venlafaxine

PPIs

tranylcypromine
meclobemide

amitriptyline
clomipramine
desipramine
doxepin
imipramine
nortriptyline

citalopram
fluoxetine
escitalopram
paroxetine

nefazodone
trazodone

duloxetine
venlafaxine

chlorpromazine
fluphenazine
haloperidol
thioridazine
perphenazine

aripiprazole
clozapine
quetiapine
risperidone

metoprolol
most beta blockers

codeine
hydrocodone prodrug
dextromethorphan
tramadol prodrug

tamoxifen prodrug

ondansetron

amitriptyline
clomipramine
doxepin
imipramine

buspirone
citalopram
escitalopram
paroxetine
sertraline
mirtazapine
nefazodone
trazodone
venlafaxine

chlorpromazine
haloperidol
perphenazine
pimozide
aripiprazole
clozapine
quetiapine
risperidone
ziprasidone

triazolo-
benzodiazepines
zaleplon
zolpidem
zopiclone

carbamazepine
valproic acid

buprenorphine
codeine
fentanyl
hydrocodone prodrug
meperidine
methadone
tramadol prodrug

statins
exceptions pravastatin
and rosuvastatin

antiarrhythmics

CCBs
beta blockers

macrolides
azithromycin
erythromycin
clarithromycin

 

 

CYP450 INHIBITORS   back to top

        1A2

2B6

2C19

2D6

3A4

amitriptyline
imipramine

fluvoxamine

duloxetine

ciprofloxacin
norfloxacin
ofloxacin

cimetidine

fluvoxamine

amitriptyline
imipramine

fluoxetine
fluvoxamine
paroxetine

PPIs 

ketoconazole

† lansoprazole is the most potent in vitro
inhibitor of 2C19

All TCAs

fluoxetine
paroxetine
bupropion

sertraline

> 100-150mg
duloxetine
fluvoxamine
citalopram

chlorpromazine
fluphenazine
haloperidol
perphenazine
thioridazine

aripiprazole
clozapine
risperidone

methadone

valproic acid mild

*quinidine*
ritonavir
cimetidine
diphenhydramine
Vistaril

metoclopramide

nefazodone
norfluoxetine
fluoxetine
fluvoxamine

haloperidol
pimozide

ciprofloxacin
norfloxacin

keto- and itraazole

diltiazem
verapamil

cimetidine
protease inhibitors
NNRTIs

CYP450 INDUCERS   back to top

1A2

2B6

2C19

2D6

3A4

cruciferous vegetables
charbroiled foods

phenobarbital

carbamazepine
valproic acid

phenobarbital
phenytoin

No Inducers!

carbamazepine
oxcarbazepine
topiramate >200mg

phenobarbital
phenytoin

rifampin
ritonavir
efavirenz
St. John’s Wort
modafinil

 

 


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